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Donna

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Moni, well at least this time of the year you can go outside if you get a hot flash!

Donna
 

pamelatransuk

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Well, to add to this instead of an original post, since I am committed now to staying a woman full time, I am picking up my first Rx of estradiol tablets tomorrow and with be taking them sub lingual. Planned Parenthood is prescribing 2 mg twice a day and 100 mg Spiro twice a day.

They would have let me do patches or injections but based on what you girls recommended to me previously, I went with the tablets and I understand I could change to injections at some point.

Twenty years ago when I was taking a low level of estradiol (.3125 mg) my boobs grew like crazy and I ended up having them reduced to save my marriage in 2001 right after 911 (yes it had that effect on me) , so I am hopeful things have not changed. Just taking Spiro for the last 8 years made them grow to half boobs so full ones are not far away.

I am looking forward to feeling different too.

Donna
Congratulations Donna and I wish you every happiness and success on resuming your HRT journey starting today 17th.

Hugs

Pamela xx
 

Confused

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Moni, well at least this time of the year you can go outside if you get a hot flash!

Donna

This is one thing that has been interesting to me. I've had a few hot flashes since being off testosterone 7 months, but not very many and they were pretty mild. Seems like my body didn't want testosterone any more than my brain does.

Hugs,
Mike
 

Katie

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I had hot flashes since I was a teenager. They pretty much went away when started HRT.
 

Linde

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I am post op. I swallow a 2 mg pill nightly and inject subQ weekly 10 mg of E2.
Why do you take such a high dose of E? I assume you are developed into a female as much as you can?

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Linde
 

Linde

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I take the 2mg pill without her knowledge. I need to disclose that to her.
@Rachel, what is the purpose that you take the 2 mg pills? In some cases that amount alone is the maintenance dose for post-op trans women.

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Linde
 

Linde

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Please Rachel, don't call us inter-sexed. We simply have intersex syndromes or conditions. Anyway, I have my doubts that any physician can look at us and determine that I/we are intersex. McGinn took a long shot there. I obviously look not like a normal cis/natal person, but I think my hypogonadism is mostly responsible for this, because my body did not masculinize caused by the lag of testosterone, respectively estrogen for feminization. Several swab tests in mouth nd nose came out with a negative for Y chromosome, an also no known cancer genes.

However, I must have some Ys, because I think I fathered one son (my only child). We now assume that some kind of mosaicism is part of my system, too. Standard blood based karyotyping came up with XX chromosomes only, bu the more accurate tissue test may show some Y's?

At this time it is only of pure academic interest to me, what the detailed makeup of my body is. A genome analysis showed that I have the genetic makeup of a post menopausal female.
I have a few conditions that are either intersex related, or simple genetic mutations, further genetic testing could shed more light on these.

My body is for sure some wild biological mixup that is not dealt with in medical textbooks.

What do you feel, your intersex syndromes are?

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Linde
 

Maybebaby56

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It depends on what type of injectible you are using as to how bad the highs and lows can be. I believe the most common injectable estradiols in the US are Valerate and Cypionate. Unlike Cypionate, Valerate tends to peek much higher but also drops off much faster, causing greater highs and lows. I've posted an article on the subject I found interesting. It's a good addition to the article Kenna provided.

Hi Donica,

I use EV because it's covered by my insurance, and I have never had any "peak-and-trough" issues. I do 0.15 mL of 40 mg/mL EV weekly and my peak blood levels are over 500 pg/mL to about 180 pg/mL at trough. I would agree, though, that this is a very subjective experience.

It's also important to note that nearly all hormones have genomic signaling pathways (binding to receptor initiates up- or down-regulation of genes) and non-genomic effects (binding to receptor causes immediate physiological response). The net physiological response is not necessarily a function of peak blood levels but Area-Under-the-Curve (AUC), which is the hormone concentration integrated over time. All estradiol esters (benzoate, validate, cypionate, etc.) give the same bioavailability, but their pharmacokinetics are different, as your article suggests.

With kindness,

Terri
 

Rachel

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Hi Linde,

I had a Nebula 30X genetic genome study done to confirm my suspicion. They had an issue with Covid in their lab and my results are delayed. I had another genome test done but I found it is only 4% of the genome. I have also had a karyotype test done at Penn.

I have issues with fats as the first 4% genome test stated. Fats such as D3, fish oils and E and others. I take very high amounts of those oils and others. My triglycerides and cholesterol are low. I mean very low.

I am post op. I inject SubQ weekly on Sundays 20mg as prescribed by my NP-c. That is high in itself for a post op woman. However, when I take a 2 mg pill (swallowed) in-combination with the sub Q I feel wonderful.

I suspect I have an allie morphism of 5 alpha reductase. My genitals did not develop correctly and as such had a unique GCS and 2 operations after the initial GCS. My doctor said to me as she was finishing my GCS in a procedure room 1 week after the initial operation, you know you are intersexed. ( I know intersexed condition but that is what she said). She elaborated by saying that in addition to size your anatomy is completely different.

The shaft skin was discarded ( think small ring of skin). I have my whole glands penis for the clit and it is very small. Dr. McGinn said there was something very different about the penile anatomy and positioning too.

When I get my nebula results I paid to use their software. I will know every allie and polymorphism. I will be able to have evidanced based hormone information. I will know once and for all the allies's and polymorphism s. I do know when I take E1 and E2 I feel wonderful. When I just inject I feel off and when I just take pills (sublingual) I feel dull. However, when I take both E1 and E2 I have zero dysphoria. Taking pills alone also gives me a roller coaster ride and I crash.

So this is me and I am close to finding out the why. It may all be in my head or it may be science based. I will know soon enough. This whole trans ordeal is something I would never wish on anyone.

Rachel
 
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Linde

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@Rachel,
the problem with those over the counter genetic tests (like 23 and me) is that they test only a very limited pair of genes (I seem to remember it is 27 pairs or so), While a full genetic tests looks at more than 4500 pairs. But no health insurance is willing to pay for this, and it is around $5000 OOP to have it done. I am really debating if it is so important to me to know what is going on with me, as long as i can manage my health with the knowledge that is available?
I know that I am intersex, and my major syndrome is De la Chapelle with negative SRY, also called XX male plus SRY-, which is pretty much the opposite of CAIS. I also know that I have hypogonadism from birth on, some call this a genetic mutation, others call it an intersex syndrome. Anyway, I never had a real puberty, and my body did not masculinize, and di not develop any secondary male sex characteristics. That gave me a shitty life as a teenager and a young man, who was supposed to be a real man, but looked more like a girl. On the other hand, it made my transition into a female very easy, because except the relative small genitalia, nothing needed to be changed.
I never had any real strong dysphoria, except after my orchi several years ago, I got very strong genital dysphoria. This des not make sense, because I was fully on femele hormones now, but when does dysphoria make sense anyway. I will get the last correction in a few days from now, and expect that any dysphoria will be gone for good. A HRT cocktail consisting of estrogen injections, and progesterone and some testosterone pills, makes me feel pretty good. My endo feels that testosterone is important for trans women, too, and mine was not measurable prior to the supplements. Maybe, you might want to look into some testosterone supplements, too?
I would be really interested to hear which intersex syndrome you have. I think pretty highly of McGinn, and she probably nailed it right.

And yes being trans is not really fun, but I feel so much better as a woman than I ever felt when I tried to be a man. I know that I am a real woman, and I am pretty sure that this is my birth gender, while I was always just a caricature of a man, falling short on al sides for being manly.

Hugs
Linde
 

Rachel

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Hi Linde,

I used Nebula Genomics and it is a 30X test. They are a good lab run by Dr. Church.

I know Dr. McGuinn very well. She inspected my genitals 13 times before GCS. I had my BA with her too. I use to go there for electrolysis but stopped in March when Covid hit. I had covid recently and will be getting the vaccine in 3 to 4 weeks. After that I will see if I am a candidate to return to Papillion for electrolysis.

One thing I will be doing is a face lift in the future. I will get pricing for that from Dr. McGinn and I will get several other prices as well. I am thinking about Dr. Telang in India too. Due to the pandemic and the unknown immunity I currently have from Covid, the unknown immunity from the RNA vaccine I may think several times about leaving the area for a surgical procedure.

A face lift is about $10,000 to $12,000 in my area. I know it is $2,500 in india but you have travel and hotel costs. Plus if there are complications I would not have health insurance. So, if you subtract the travel costs and factor in the potential of a complication then maybe going to India may be perhaps $7,000. Plus the unknown surgical and health risks. India just has a high potential of heath risks and food issues. However, $7,000 vs $12,000 is pretty large.
 

Linde

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@ Rachel, there are several members here in the forum who had facial surgery done. You may want to start a subject heading soliciting their experience with these procedures>
I am lucky, I have some kind of genetic mutation that makes my skin me aging very slowly (I also did not have any puberty concerning my skin changing). I hope that I can maintain my looks as long as possible with creams and lotions. I would be very scared about any facial surgery, because it looks very painful to me, and I am a bit wimpy, and a cry baby!

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Linde
 

Donna

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I have issues with fats as the first 4% genome test stated. Fats such as D3, fish oils and E and others. I take very high amounts of those oils and others. My triglycerides and cholesterol are low. I mean very low.
Hi Rachel,

I am interested in what you said about the fats that you take. Do you take them to lower your triglycerides and cholesterol? I have high cholesterol and can't take statins because they give me severe leg cramps at night, so I am trying to control my cholesterol with diet and daily exercise. I read a book on lowering cholesterol and it suggested 10 things, oatmeal everyday as well as around 30 almonds and Metamucil along with exercise, and certain kinds of margarine, and 5 other things I don't want to eat, but it did come down significantly doing the 5 things I am doing. Adding the oils seems easy enough.

Donna
 

Linde

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Just a little bit of extra info here. for those of you who are taking progesterone, it was found that this has the best results if taken WITH food, preferably fatty foods, which would be counter productive if you want to lower your fat intake.

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Linde
 

Rachel

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Hi,

I eat keto 40 grams or less per day of net carbs. I eat using time restricted feeding over a 6 hour window 1200 hrs to 1800 hrs (Dr. Satchidananda Panda). Almonds are pretty much a staple for keto ( I follow Dr. Annette Bosworth) in the form of almond flour. I eat a lot of fat. I would never eat a hydrogenated fat (frans fat or margarine). Saturated fats are my preferred fat sources. However, I do eat fish oils, krill oil, Vitamin D (hormone) and E. One genome test (4% of genome, not good) said I have a polymorphism for vitamin D and E. I take a high amount of these fats.

I have my full 30 time scanned genome being mapped by Nebula (Dr. Church's Lab). I paid to use their software to find all allies (less than 1 percent of the population)and polymorphisms (greater than 1 percent of the population). I believe this should be the basis of nutrition and a starting point. From that point I will be able to confirm my suspicions and will go into detail if that proves correct. It could all be in my head and wishing for a reason has been a life long question.

I do high intensity exercise but not high duration. I do 100 squats, 21 flights of steps and 100 push ups at 0500 at work. I stopped due to getting Covid. I have some inflammation and do not want to aggravate the condition and I am really tired easily at present but getting better quickly. I think mid January before I start back if I feel 100%. Vascular inflammation and clots are a later stage occurrence for Covid. I really do not want to die ( way cool to think that).

We lost another co-worker in our department last night. 2 within 2 weeks from sudden heart attack in bed at night. I know some think maks are not a help. Dr. Pleasure is a researcher where I work. He said that wearing a mask reduces the incidents of covid. If you get covid the viral load will be lower (assuming it is not acquired at home). Your innate immune response will be able to deal with a low viral load until your T cells can respond. Assuming you are below a certain age and do not have co morbidities. So wear a mask and keep your distance so if you get covid you can respond well to the infection. I unfortunately had a coworker that was in an office next to mine for a long time (more than 5 work days) with Covid. He decided to come to work even though he felt sick. Thank you very much you very thoughtful person.

Rachel
 

Linde

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@ Rachel, my medical specialty is Infection Control & Prevention. I worked in the labs of the best know mask producer, and I was involved in efficiency testing, et.\c. of those masks. Dr. Pleasure is pretty right, and when the masks are worn properly and changed or laundered frequently, reduces the viral contamination burden that is inhaled, by quite some bit.

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Linde
 

Kenna

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Just a little bit of extra info here. for those of you who are taking progesterone, it was found that this has the best results if taken WITH food, preferably fatty foods, which would be counter productive if you want to lower your fat intake.
Hi @Linde
Can you share the reference on that please? I'm taking Prometrium but the instruction specifically say "Do not take Prometrium with food as this may affect the way Prometrium works."
Thanks
-Kenna
 

Linde

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Hi @Linde
Can you share the reference on that please? I'm taking Prometrium but the instruction specifically say "Do not take Prometrium with food as this may affect the way Prometrium works."
Thanks
-Kenna
Kenna, I am ready to drive to Minnesota, and don't have time to find the detail anymore, but here is the entire study report.

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Linde
 

Rachel

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I sit (required by JCAHO) on the IP&C committee and the Bio response committee and am a member of the Bio-Response team. At our IP&C committee we have the head of Philly's Health Department. I have worked with her for 34 years and she is awesome. Same for our IP&C Medical director.

When we enter a covid-19 patient room or have a non-rule out (waiting for the rapid test results) ( we were the first to gain approval for a rapid test in PA. I do not now about the country) a N95, eye shield and standard precautions are used.

Surgical (2 ply) masks can not stop a coughing aerosolized Covid-19 virus droplets. It reduces the CFU (colony forming units). Distance reduces CFU units. Less time reduces CFU. These are facts.

I wore a 2 ply surgical mask at work but not in my office (except in the covid ward where I used the above protocal). I kept my office door open. My office is about 20 feet long (because of the floor plan). The Hospital is hepa filtered in most areas and it is hepa filtered in the patient tower where my office is located. We use 99.9995 of the 0.4 micron participial efficiency filters in the AHU's. I contracted Covid 19 and wore a mask 100% of the time other than in my office. I returned to work 10 days after contracting Covid 19 as per CDC guidance.

I worked in the COVID wards for 16 12 hour shifts. I donned and doffed the medical staff. Bedside procedures were performed there and well as the ED. I did not get covid. Many of the staff I worked with did get covid. Many of the Nursing staff did get covid. I am A positive blood as well. All clusters are reported the the state DOH and are public information. We have had clusters.

Surgical masks reduce viral load. Most surgical site infections are from bio shedding. We designed our OR's with hepa filtration 100% and use a micro environment macro environment air distribution with low and high return and exhaust. That way clean hepa air washes over the patient and outward across the surgeons and then out of the OR.

There are many factors that influence covid spread. I am getting my 1st covid vaccine injection Thursday ( I can work from home Friday if need be). I had covid. So if I ride an elevator with you and we are wearing surgical masks and I had covid and I recovered and I had the vaccine the mask will not have prevented me from infecting you. My immunity will have protected you from contracting covid. At least for now.

Rachel
 

magic_michelle

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My skin is super sensitive, to ridiculous levels and, perhaps because of the skin reaction, I couldn’t get the patches to stay on reliably and definitely not if I planned on doing anything such as exercise, driving, walking, showering... actually just anything. Having wanted to move to injections myself I elected to move to estrogel instead as my endo explained to me that as the injections are compounded at a pharmacy they do not have the same degree of consistency than the injections sourced overseas and can vary wildly. It’s hard to say what effect exactly I can attribute to the change from patches to gel as I also switched blockers from cyproterone to bicalutamide at the same time but the changes I have seen in the last month have been profound. We’re all different and you shouldn’t be afraid to keep looking until you find what works for you.
 
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